Unfortunately the quality of the Bioconductor packages varies wildly, from pretty good to downright abysmal. Some can't even work: take a look at this one[1],

Unfortunately the quality of the Bioconductor packages varies wildly, from pretty good to downright abysmal. Some can't even work: take a look at this one[1], which is part of the current release of BioC: it will never work because the hardcoded host there is no longer functioning and the author wrote that for their master's thesis and have since moved on. In addition, there's no centralized bug reporting, and some packages use GH issues while for others you may need to email the author and hope for the best (sometimes works, sometimes doesn't). I use BioC regularly every day because I have no other alternatives, but its main advantage is the sheer numbers of packages available for almost every bioinformatic niche, rather than the quality of the packages themselves. [1] https://github.com/AllenTiTaiWang/anamiR/blob/7a7a133c553f8c3262cec65d86735fe121049456/R/database_support.R#L80 https://github.com/AllenTiTaiWang/anamiR/blob/7a7a133c553f8c...