If you create the pool with ashift=12, you're fine. The only hazard is if you have an ashift=9 pool (the default, IIRC) and later add a 4096 byte sector drive,

If you create the pool with ashift=12, you're fine. The only hazard is if you have an ashift=9 pool (the default, IIRC) and later add a 4096 byte sector drive, you might lose some write perf. It probably doesn't matter for homelab use. There aren't many 512 byte drives any more. You'll be fine.