>Do you pick some front-end framework such as react.js/angular.js/vue.js, and some backend framework (nodejs+express, django, whatever..) and do everything by h

>Do you pick some front-end framework such as react.js/angular.js/vue.js, and some backend framework (nodejs+express, django, whatever..) and do everything by hand? Basically yes but generally you try to do as little as possible by hand by leveraging the framework features and usually what frameworks everyone in your company are familiar with.