4 ms·
Hippocrates is said to have claimed that "all disease starts in the gut". There's been some very interesting research coming out the last few years that seem to
by atombender 7y ago
Hippocrates is said to have claimed that "all disease starts in the gut". There's been some very interesting research coming out the last few years that seem to tie autoimmune diseases such as psoriasis [1] [2] to the gut.
It's been known for a while that some gut disorders, including Crohn's, can manifest as skin lesions of various kinds, and bowel bypass patients can also develop skin symptoms. It's also known for a while that autoimmune patients have less bacterial diversity in their gut, and an increased abundance of certain types of bacteria, especially in the small intestine. Research has found that in such patients, gut bacteria can migrate from the gut to the bloodstream and then to the skin. Psoriasis patients, for example, have a much higher gut permeability than non-psoriatics (not to be confused with the pseudoscientific Internet hysteria around "leaky gut"!) and have deficient bile acids.
Treatment would involve resetting the gut somewhat by eradicating the known pathogens. Astonishingly, a Hungarian study in 2003 [3], which used an experimental treatment with bile acid supplementation, was able to completely clear psoriasis in 78% of its subjects (even more in a second, more acute group), which is unheard of, and about 58% were still clear 2 years later. I don't know why that study hasn't revolutionized things; it's only been cited 11 times according to Scopus.com.
[1] https://www.ncbi.nlm.nih.gov/pubmed/29908580 https://www.ncbi.nlm.nih.gov/pubmed/29908580
[2] https://www.nature.com/articles/nrmicro2974 https://www.nature.com/articles/nrmicro2974
[3] https://www.sciencedirect.com/science/article/pii/S0928468003000427 https://www.sciencedirect.com/science/article/pii/S092846800...
- Jacob_G 7y agoYou can reverse intestinal permeability though diet. However, there is no money in it and neither is it a complicated treatment. Thus, the papers about it won't get published in prestigious journals.
- atombender 7y agoInteresting. Links?
- Madmallard 7y ago[citation needed]
- tsomctl 7y agoBrain Maker: The Power of Gut Microbes to Heal and Protect Your Brain for Life by Perlmutter I have a theory that fad diets like keto, paleo, primal blueprint, low fodmap, whole 30 (of which there are numerous people claiming they have major improvements) really work because they influence the gut biome.
- throw345hn 7y agoI cant speak for other diets but I follow low fodmap diet as I suffer from IBS. I always assumed that I was prescribed that diet to influence the gut bacteria. I mean the bacteria ferment on high fodmap foods and bloat and distend your stomach. Talking about low fodmap specifically I wouldnt call it fad as it has been and is being researched and has shown to be effective to help with IBS, maybe not so much for other conditions. Personally I have found it helpful in reducing the symptoms that I have.
- rorykoehler 7y agoKeto is working for me to treat AS specifically for this reason. Had to experiment a long time to find the right diet. If I stray I flare up pretty quickly.
- Madmallard 7y agohttps://www.thecut.com/2015/06/problem-with-the-grain-brain-doctor.html https://www.thecut.com/2015/06/problem-with-the-grain-brain-... :thinking: I don't know about this guy. I got that link from quackwatch.
- Nuzzerino 7y agoI'm curious to know much the journal prestige actually factors in to the odds of the described medical technique eventually becoming a usable clinical practice. I wonder if anyone has done that kind of analysis and published results.