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Great post and thanks for sharing your learnings. A couple of quick questions: Was the 25TB raw data gathered from a single human genome? What would be the s

Great post and thanks for sharing your learnings. A couple of quick questions: Was the 25TB raw data gathered from a single human genome? What would be the size in bytes of a unique genomic fingerprint once raw data is all fully processed into high confidence base values? (including non-coding regions) If we just look at coding regions and further compress by only looking at SNPs, how many bytes is that? Considering that each base has ~2B of information... it would be super interesting to know how much space it takes to describe our uniqueness!

markus_zhang 7y ago
Sorry I saw this article and thought it was pretty interesting. This is NOT my article but I'd like to know what others would do under this situation. BTW not sure, but is it OK to post other's article here? Maybe I should add a short commentary in the title.
- innomatics 7y ago
  I think it's fine. The author might show up otherwise others with interest in the area might reply.
- kreetx 7y ago
  You don't even need to say it's not yours, probably most that is posted here isn't from the author.
- kohtatsu 7y ago
  The default assumption is that it's not your article, unless you prepend "Show HN" (or there's something obvious like your username matching the domain name).
- nstrayer 7y ago
  Of course! Glad you posted it. I didn't realize that many people would find it interesting.
eesmith 7y ago
Q: "Was the 25TB raw data gathered from a single human genome?" Essay: "Each row contained a data for a single SNP for a single person." ... "There were ~2.5 million SNPS and ~60 thousand people" Statement: "it would be super interesting to know how much space it takes to describe our uniqueness" Genome size is "3,234.83 Mb (Mega-basepairs) per haploid genome" says https://en.wikipedia.org/wiki/Human_genome https://en.wikipedia.org/wiki/Human_genome . However, question of uniqueness depends on your model. We are all unique. If you have human genomes, then use a reference template and only list those which differ. Eg, https://en.wikipedia.org/wiki/Compression_of_Genomic_Sequencing_Data https://en.wikipedia.org/wiki/Compression_of_Genomic_Sequenc... .
sszz 7y ago
In order to uniquely identify, not a lot of space! A recent paper puts it at 50 SNPs (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785835/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785835/). Describing your total unique genetic profile would obviously require a lot more space, and wouldn't be constant across individuals/ancestral backgrounds (e.g. there's more genetic diversity in people of African descent).

markus_zhang 7y ago

Sorry I saw this article and thought it was pretty interesting. This is NOT my article but I'd like to know what others would do under this situation. BTW not sure, but is it OK to post other's article here? Maybe I should add a short commentary in the title.

innomatics 7y ago
I think it's fine. The author might show up otherwise others with interest in the area might reply.
kreetx 7y ago
You don't even need to say it's not yours, probably most that is posted here isn't from the author.
kohtatsu 7y ago
The default assumption is that it's not your article, unless you prepend "Show HN" (or there's something obvious like your username matching the domain name).
nstrayer 7y ago
Of course! Glad you posted it. I didn't realize that many people would find it interesting.

eesmith 7y ago

Q: "Was the 25TB raw data gathered from a single human genome?" Essay: "Each row contained a data for a single SNP for a single person." ... "There were ~2.5 million SNPS and ~60 thousand people" Statement: "it would be super interesting to know how much space it takes to describe our uniqueness" Genome size is "3,234.83 Mb (Mega-basepairs) per haploid genome" says https://en.wikipedia.org/wiki/Human_genome https://en.wikipedia.org/wiki/Human_genome . However, question of uniqueness depends on your model. We are all unique. If you have human genomes, then use a reference template and only list those which differ. Eg, https://en.wikipedia.org/wiki/Compression_of_Genomic_Sequencing_Data https://en.wikipedia.org/wiki/Compression_of_Genomic_Sequenc... .

sszz 7y ago

In order to uniquely identify, not a lot of space! A recent paper puts it at 50 SNPs (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785835/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785835/). Describing your total unique genetic profile would obviously require a lot more space, and wouldn't be constant across individuals/ancestral backgrounds (e.g. there's more genetic diversity in people of African descent).