3 ms·
I have a mild objection to this headline: in context, "intriguing" plants the suggestion that there were positive results, or at least potential avenues of futu
by Analemma_ 7y ago
I have a mild objection to this headline: in context, "intriguing" plants the suggestion that there were positive results, or at least potential avenues of future research, whereas the article body states pretty clearly that there was no effect:
> In the end, the researchers conclude the LSD microdoses did not affect the majority of mood, cognition and physiological measures that were examined.
It goes on to say:
> However, it is also noted this is not at all a final determination on the ultimate veracity of LSD microdosing, either as a cognitive booster, or an anti-depressant. This is merely the first step in trying to empirically understand the acute effects of this oft-reported anecdotal phenomenon.
More research is always good, but it's important to remember that cases like this where the purported effects are on things like mood and creativity (which are tricky to measure and probably have significant day-to-day variation) are going to be especially vulnerable to placebo effects and wishful thinking. When you combine this with gwern's also-negative result, I don't think you can escape the conclusion that LSD microdosing probably does nothing.
- derefr 7y agoIf a "microdose" is defined as "a dose that has no perceivable effects", is there a term for a dose one step up from that: the weakest dose whose effect can be perceived? I have a feeling that a lot of the people who think microdosing works, are actually taking that level of dose, rather than a true microdose.
- ivarv 7y agoThe study noted that the highest dose administered (25ug) was perceptible so I wonder if you could isolate the results of just the cohort that received that dose. That said, it would negate the blind on the study and all data would then be suspicious.
- sideshowb 7y agoThreshold dose is the term you're looking for
- AstralStorm 7y agoYou cannot assume a null result without testing against it rigorously. Gwern level of tests are way not rigorous nor sensitive enough. Which is why this is much more useful. Blinding is relatively easy with substances that are active at very low doses and have relatively unpredictable effects.