3 ms·
Having lost my own father to Parkinson's Disease (PD), my mother-in-law to a different progressive neurological disease and now watching my father-in-law walk t
by mswen 7y ago
Having lost my own father to Parkinson's Disease (PD), my mother-in-law to a different progressive neurological disease and now watching my father-in-law walk through PD as well, your comment caught my attention. So I wondered if clinicians are doing fecal transplants to restore function in PD patients? A bit of searching and scanning found the following review
Gut microbiota: Implications in Parkinson's disease
Parashar, Arun et al.
Parkinsonism & Related Disorders, Volume 38, 1 - 7 [1]
Key passage
"This autonomic input from the gut is connected to the limbic system of the brain, which includes the hippocampus, the amygdala, and the limbic cortex. Limbic cortex is of importance since it regulates motor functions, which are impaired in PD. The connection between the limbic system and ANS is a critical factor underlying between gut health and brain & behavior [77]. Recently, it was found that fecal transplant from PD patients exacerbated motor impairment with reduction in Lachnospiraceae and Ruminococceae in recipient mice model of PD. Interestingly, same genera were significantly reduced in fecal samples from PD patients [27] link below [2].
Several case reports of patients with PD, multiple sclerosis, myoclonus dystonia, Alzheimer's disease, chronic fatigue syndrome, and autism have shown that FMT and/or antibiotic regimen was helpful in treating GIT symptoms like constipation, ulcerative colitis, and bowel disorders. Further, the therapy was helpful in relieving several non-GIT symptoms too"
[1]https://www.prd-journal.com/article/S1353-8020(17)30036-6/fulltext https://www.prd-journal.com/article/S1353-8020(17)30036-6/fu...
[2] https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.26307 https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.26307