4 ms·

Really? Wikipedia lists: > single doses over 7000 mg often causing life-threatening respiratory depression, and higher doses still inducing bradycardia and car

Really? Wikipedia lists: > single doses over 7000 mg often causing life-threatening respiratory depression, and higher doses still inducing bradycardia and cardiac arrest. — https://en.m.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid https://en.m.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid As far as I know the danger with depressants is not necessarily poisoning but also cardiac and respiratory arrest. Do you know what the LD50 of GHB is meant to be? I can’t find it.

beenBoutIT 7y ago
The typical nightly dose for adults is 6-9g and it doesn't cause respiratory depression. Wikipedia isn't a good source on its own. https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults
et2o 7y ago
Replying to the other commentor: The very first listing on the box warning for Xyrem is respiratory depression.
- beenBoutIT 7y ago
  The warning has to do with bad combinations. Sedatives/alcohol/etc mixed with GHB can cause respiratory depression and death. On its own 'GHB slows and deepens respiration (causing no net effect on blood gasses) and it slows heart rate'. https://life-enhancement.com/pages/the-truth-about-ghb-steven-fowkes-testifies-to-the-california-state-legislature-committee https://life-enhancement.com/pages/the-truth-about-ghb-steve...
  - et2o 7y ago
    That is just completely inaccurate. The black box warning does not apply to only combinations. Don't take medical advice from "life-enhancement.com". There is an extensive body of peer reviewed literature. See for example https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ > "The primary effect of GHB on respiration was a dose-dependent decrease in respiratory rate, accompanied by an increase in tidal volume, resulting in little change in minute volume." Eventually tidal volume cannot be increased to compensate for decrease in RR. GHB is dangerous because this change occurs at the margins of recreational dosages. This is especially pronounced when combined with other respiratory depressants. I am a medical professional, not making this up. Please do not spread harmful misinformation.
    - beenBoutIT 7y ago
      The guy's personal views aren't sufficient to make what he's saying untrue. Everything will kill you at some dose, GHB having a lethal dosage doesn't make it especially dangerous. 'Morse et al. [7] have demonstrated the effects of GHB on breathing. A decrease in respiratory rate occurs, accompanied by a compensatory increase in tidal volume, allowing minute volume to be maintained until doses approach lethality. The concomitant ingestion of ethanol typically alters the concentration-effect relationship, leading to respiratory depression when the compensatory increase in tidal volume is avoided as seen in cases where GHB is administered alone. This deleterious effect from combining GHB and ethanol could be avoided through the administration of GABA-B receptor antagonists. These receptors seem to be involved in its development.' http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respiration.php?aid=10953 http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respira...
      - et2o 7y ago
        You realize that I referenced the same article? I already addressed this. I also have never seen that journal you referenced; it does not appear to be indexed in PubMed and it's strange. You cannot indefinitely increase tidal volume. This study was done in mice. There are established LD50s for GHB which are not far from recreational dosages. GHB causes respiratory depression. It is worse when combined with other agents like ethanol, which it often is. I already wrote that.

beenBoutIT 7y ago

The typical nightly dose for adults is 6-9g and it doesn't cause respiratory depression. Wikipedia isn't a good source on its own. https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults

et2o 7y ago

Replying to the other commentor: The very first listing on the box warning for Xyrem is respiratory depression.

beenBoutIT 7y ago
The warning has to do with bad combinations. Sedatives/alcohol/etc mixed with GHB can cause respiratory depression and death. On its own 'GHB slows and deepens respiration (causing no net effect on blood gasses) and it slows heart rate'. https://life-enhancement.com/pages/the-truth-about-ghb-steven-fowkes-testifies-to-the-california-state-legislature-committee https://life-enhancement.com/pages/the-truth-about-ghb-steve...
- et2o 7y ago
  That is just completely inaccurate. The black box warning does not apply to only combinations. Don't take medical advice from "life-enhancement.com". There is an extensive body of peer reviewed literature. See for example https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ > "The primary effect of GHB on respiration was a dose-dependent decrease in respiratory rate, accompanied by an increase in tidal volume, resulting in little change in minute volume." Eventually tidal volume cannot be increased to compensate for decrease in RR. GHB is dangerous because this change occurs at the margins of recreational dosages. This is especially pronounced when combined with other respiratory depressants. I am a medical professional, not making this up. Please do not spread harmful misinformation.
  - beenBoutIT 7y ago
    The guy's personal views aren't sufficient to make what he's saying untrue. Everything will kill you at some dose, GHB having a lethal dosage doesn't make it especially dangerous. 'Morse et al. [7] have demonstrated the effects of GHB on breathing. A decrease in respiratory rate occurs, accompanied by a compensatory increase in tidal volume, allowing minute volume to be maintained until doses approach lethality. The concomitant ingestion of ethanol typically alters the concentration-effect relationship, leading to respiratory depression when the compensatory increase in tidal volume is avoided as seen in cases where GHB is administered alone. This deleterious effect from combining GHB and ethanol could be avoided through the administration of GABA-B receptor antagonists. These receptors seem to be involved in its development.' http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respiration.php?aid=10953 http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respira...
    - et2o 7y ago
      You realize that I referenced the same article? I already addressed this. I also have never seen that journal you referenced; it does not appear to be indexed in PubMed and it's strange. You cannot indefinitely increase tidal volume. This study was done in mice. There are established LD50s for GHB which are not far from recreational dosages. GHB causes respiratory depression. It is worse when combined with other agents like ethanol, which it often is. I already wrote that.