5 ms·

I agree with what you're saying but that chart isn't accurate at all. GHB isnt toxic except at massive doses, it metabolizes into water and carbon dioxide and i

I agree with what you're saying but that chart isn't accurate at all. GHB isnt toxic except at massive doses, it metabolizes into water and carbon dioxide and is a first-line prescription treatment for narcolepsy.

nothrabannosir 7y ago
Really? Wikipedia lists: > single doses over 7000 mg often causing life-threatening respiratory depression, and higher doses still inducing bradycardia and cardiac arrest. — https://en.m.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid https://en.m.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid As far as I know the danger with depressants is not necessarily poisoning but also cardiac and respiratory arrest. Do you know what the LD50 of GHB is meant to be? I can’t find it.
- beenBoutIT 7y ago
  The typical nightly dose for adults is 6-9g and it doesn't cause respiratory depression. Wikipedia isn't a good source on its own. https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults
- et2o 7y ago
  Replying to the other commentor: The very first listing on the box warning for Xyrem is respiratory depression.
  - beenBoutIT 7y ago
    The warning has to do with bad combinations. Sedatives/alcohol/etc mixed with GHB can cause respiratory depression and death. On its own 'GHB slows and deepens respiration (causing no net effect on blood gasses) and it slows heart rate'. https://life-enhancement.com/pages/the-truth-about-ghb-steven-fowkes-testifies-to-the-california-state-legislature-committee https://life-enhancement.com/pages/the-truth-about-ghb-steve...
    - et2o 7y ago
      That is just completely inaccurate. The black box warning does not apply to only combinations. Don't take medical advice from "life-enhancement.com". There is an extensive body of peer reviewed literature. See for example https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ > "The primary effect of GHB on respiration was a dose-dependent decrease in respiratory rate, accompanied by an increase in tidal volume, resulting in little change in minute volume." Eventually tidal volume cannot be increased to compensate for decrease in RR. GHB is dangerous because this change occurs at the margins of recreational dosages. This is especially pronounced when combined with other respiratory depressants. I am a medical professional, not making this up. Please do not spread harmful misinformation.
      - beenBoutIT 7y ago
        The guy's personal views aren't sufficient to make what he's saying untrue. Everything will kill you at some dose, GHB having a lethal dosage doesn't make it especially dangerous. 'Morse et al. [7] have demonstrated the effects of GHB on breathing. A decrease in respiratory rate occurs, accompanied by a compensatory increase in tidal volume, allowing minute volume to be maintained until doses approach lethality. The concomitant ingestion of ethanol typically alters the concentration-effect relationship, leading to respiratory depression when the compensatory increase in tidal volume is avoided as seen in cases where GHB is administered alone. This deleterious effect from combining GHB and ethanol could be avoided through the administration of GABA-B receptor antagonists. These receptors seem to be involved in its development.' http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respiration.php?aid=10953 http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respira...
        et2o 7y ago
        You realize that I referenced the same article? I already addressed this. I also have never seen that journal you referenced; it does not appear to be indexed in PubMed and it's strange. You cannot indefinitely increase tidal volume. This study was done in mice. There are established LD50s for GHB which are not far from recreational dosages. GHB causes respiratory depression. It is worse when combined with other agents like ethanol, which it often is. I already wrote that.
et2o 7y ago
What it metabolizes into isn't very important. GHB is quite dangerous when used alongside other respiratory depressants, most commonly alcohol. They have a synergistic effect on respiratory depression. It's also pretty habit-forming.
- hliuhl 7y ago
  What a drug is metabolised into is sometimes how it treats a patient. Grapefruit can slow down some of the P450 enzymes so drugs like heart condition drugs can kill, and Viagra in combination with grapefruit will give you a priaprism that lasts for hours. 2 Litres of grapefruit juice + 50mg of Viagra to be exact is all you need, and to go down, you need a visit to the A&E dept who will inject both sides of your penis with andrenaline, or getting a couple of epipens from the darkweb could also save you a trip to the A&E dept if you want to do it yourself. Tobacco speeds up the metabolise of some drugs again altering some of the P450 enzymes, like caffeine so instead of it lasting in the body for about 8hrs, its cleared in 4hrs, yet some other prescription drugs including some female contraceptives can make caffeine last in the body for over a day, which explains why some people are sensitive to it. Viagra and poppers is also a big no no as it can cause a fatal drop in blood pressure, but so can ingesting large quantities of potassium. Paracetamol also slows down some P450 enzymes so when combined with alcohol, the alcohol can reach toxic levels in the body and kill. Its an easy suicide method if you know the right amounts to take. To bypass the liver which is like a safety net for the body, inhale drugs like cocaine, hold them under your tongue as the skin is thin there or stick them up your bum which also has thin skin and thus easily absorbed. Pretty much anything is dangerous at the wrong dose, the wrong delivery method and those Lethal Doses can be affected by other foods and drugs which many people may not think anything of, so just be careful.
  - et2o 7y ago
    I'm familiar with all of that, which does not apply to GHB.

nothrabannosir 7y ago

Really? Wikipedia lists: > single doses over 7000 mg often causing life-threatening respiratory depression, and higher doses still inducing bradycardia and cardiac arrest. — https://en.m.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid https://en.m.wikipedia.org/wiki/Gamma-Hydroxybutyric_acid As far as I know the danger with depressants is not necessarily poisoning but also cardiac and respiratory arrest. Do you know what the LD50 of GHB is meant to be? I can’t find it.

beenBoutIT 7y ago
The typical nightly dose for adults is 6-9g and it doesn't cause respiratory depression. Wikipedia isn't a good source on its own. https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults https://www.xyremhcp.com/xyrem-dosing-and-titrating-adults
et2o 7y ago
Replying to the other commentor: The very first listing on the box warning for Xyrem is respiratory depression.
- beenBoutIT 7y ago
  The warning has to do with bad combinations. Sedatives/alcohol/etc mixed with GHB can cause respiratory depression and death. On its own 'GHB slows and deepens respiration (causing no net effect on blood gasses) and it slows heart rate'. https://life-enhancement.com/pages/the-truth-about-ghb-steven-fowkes-testifies-to-the-california-state-legislature-committee https://life-enhancement.com/pages/the-truth-about-ghb-steve...
  - et2o 7y ago
    That is just completely inaccurate. The black box warning does not apply to only combinations. Don't take medical advice from "life-enhancement.com". There is an extensive body of peer reviewed literature. See for example https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400846/ > "The primary effect of GHB on respiration was a dose-dependent decrease in respiratory rate, accompanied by an increase in tidal volume, resulting in little change in minute volume." Eventually tidal volume cannot be increased to compensate for decrease in RR. GHB is dangerous because this change occurs at the margins of recreational dosages. This is especially pronounced when combined with other respiratory depressants. I am a medical professional, not making this up. Please do not spread harmful misinformation.
    - beenBoutIT 7y ago
      The guy's personal views aren't sufficient to make what he's saying untrue. Everything will kill you at some dose, GHB having a lethal dosage doesn't make it especially dangerous. 'Morse et al. [7] have demonstrated the effects of GHB on breathing. A decrease in respiratory rate occurs, accompanied by a compensatory increase in tidal volume, allowing minute volume to be maintained until doses approach lethality. The concomitant ingestion of ethanol typically alters the concentration-effect relationship, leading to respiratory depression when the compensatory increase in tidal volume is avoided as seen in cases where GHB is administered alone. This deleterious effect from combining GHB and ethanol could be avoided through the administration of GABA-B receptor antagonists. These receptors seem to be involved in its development.' http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respiration.php?aid=10953 http://dual-diagnosis.imedpub.com/sodium-oxybate-and-respira...
      - et2o 7y ago
        You realize that I referenced the same article? I already addressed this. I also have never seen that journal you referenced; it does not appear to be indexed in PubMed and it's strange. You cannot indefinitely increase tidal volume. This study was done in mice. There are established LD50s for GHB which are not far from recreational dosages. GHB causes respiratory depression. It is worse when combined with other agents like ethanol, which it often is. I already wrote that.

et2o 7y ago

What it metabolizes into isn't very important. GHB is quite dangerous when used alongside other respiratory depressants, most commonly alcohol. They have a synergistic effect on respiratory depression. It's also pretty habit-forming.

hliuhl 7y ago
What a drug is metabolised into is sometimes how it treats a patient. Grapefruit can slow down some of the P450 enzymes so drugs like heart condition drugs can kill, and Viagra in combination with grapefruit will give you a priaprism that lasts for hours. 2 Litres of grapefruit juice + 50mg of Viagra to be exact is all you need, and to go down, you need a visit to the A&E dept who will inject both sides of your penis with andrenaline, or getting a couple of epipens from the darkweb could also save you a trip to the A&E dept if you want to do it yourself. Tobacco speeds up the metabolise of some drugs again altering some of the P450 enzymes, like caffeine so instead of it lasting in the body for about 8hrs, its cleared in 4hrs, yet some other prescription drugs including some female contraceptives can make caffeine last in the body for over a day, which explains why some people are sensitive to it. Viagra and poppers is also a big no no as it can cause a fatal drop in blood pressure, but so can ingesting large quantities of potassium. Paracetamol also slows down some P450 enzymes so when combined with alcohol, the alcohol can reach toxic levels in the body and kill. Its an easy suicide method if you know the right amounts to take. To bypass the liver which is like a safety net for the body, inhale drugs like cocaine, hold them under your tongue as the skin is thin there or stick them up your bum which also has thin skin and thus easily absorbed. Pretty much anything is dangerous at the wrong dose, the wrong delivery method and those Lethal Doses can be affected by other foods and drugs which many people may not think anything of, so just be careful.
- et2o 7y ago
  I'm familiar with all of that, which does not apply to GHB.