4 ms·
> "Sure, but I think the whole of the field has rabbit-holed on lipids for too long, ignoring actual causal factors." LDL cholesterol is by far the best establ
by carbocation 7y ago
> "Sure, but I think the whole of the field has rabbit-holed on lipids for too long, ignoring actual causal factors."
LDL cholesterol is by far the best established causal risk factor for coronary artery disease.
> "Check the evalocumab trial I posted, ACM was actually slightly worse in the PCSK9 side of the trial."
All cause mortality was significantly lower in Odyssey: https://www.nejm.org/doi/full/10.1056/NEJMoa1801174 https://www.nejm.org/doi/full/10.1056/NEJMoa1801174
- virtuallynathan 7y ago> LDL cholesterol is by far the best established causal risk factor for coronary artery disease. Is it causal, or is it a risk factor? I'd say at best it is "necessary but not sufficient". CVD risk calculators don't even take LDL-C into account, that's how good of a marker it is.