If DNA doesn't code for everything then you deserve the Nobel prize because there isn't any other mechanism for how cells derive structure and function from tha

If DNA doesn't code for everything then you deserve the Nobel prize because there isn't any other mechanism for how cells derive structure and function from that is known outside of this conversation. What else codes for PTM, ubiquitination, and basal level expression. >DNA dictates whether a protein can be expressed or not, but not whether it is expressed in any particular cell, how much is expressed, or whether and how much is activated or otherwise modified over time. It does determine whether it is expressed and how much is expressed. The difference between being a heterzygote and homozygote for certain proteins literally determines whether one will have fully protein expression or half. When a gene is doubled in the genome its expression is usually doubled as well. >Because there are cases (probably the majority) where drug-gene interaction is insufficient. 80-90% of drugs are metabolized by CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP3A5 to which we are starting to isolate polymorphisms in the general public. This isn't that difficult to do the genotyping, but what's limited right now is correlating polymorphism to what the side effect of drug is; this is going to be purely a time and data collection issue. I'm curious what your examples would be, because the majority of cases I've been apart of it's a simple base pair substitution that cause deleterious effects.