3 ms·

For the life of me I really don’t understand why the regulators haven’t clamped down on statins. Sure, it lowers your cholesterol, but unless if you’re in a ver

For the life of me I really don’t understand why the regulators haven’t clamped down on statins. Sure, it lowers your cholesterol, but unless if you’re in a very specific population it doesn’t move your all cause mortality risk one iota. All while costing the patient money and causing some pretty nasty side effects too.

viraptor 7y ago
> but unless if you’re in a very specific population it doesn’t move your all cause mortality risk one iota Have you got a link to some relevant research?
- village-idiot 7y ago
  Sure do! I typically defer to Mark Sisson for this kind of stuff, who’s very good at linking in relevant research. https://www.marksdailyapple.com/the-evidence-continues-to-mount-against-statins/ https://www.marksdailyapple.com/the-evidence-continues-to-mo...
semenko 7y ago
Probably because most data disagree with this comment. There's a ~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL. The CTT is probably the best summary of these data: https://www.cttcollaboration.org/ https://www.cttcollaboration.org/
- virtuallynathan 7y ago
  > "~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL." Is that a composite endpoint of vascular events AND mortality? From TheNNT: "It takes 5 years of daily statin therapy to achieve a 1.6% chance of avoiding a heart attack, and a 0.37% chance of avoiding a stroke. Most disappointing, statins seem unable to prevent death in this group. And most concerning, the drugs may increase diabetes, a serious and life-altering disease." (Primary Prevention) http://www.thennt.com/nnt/statins-for-heart-disease-prevention-without-prior-heart-disease-2/ http://www.thennt.com/nnt/statins-for-heart-disease-preventi...
- deleted 7y ago
  [deleted]
- village-idiot 7y ago
  That would be the same CTT that makes money from the makers of Statins and has been accused of being insufficiently transparent around their studies[0]. 0 http://www.drjohnm.org/2014/06/growing-doubt-on-statin-drugs-the-problem-of-drug-lifestyle-interaction/ http://www.drjohnm.org/2014/06/growing-doubt-on-statin-drugs...

viraptor 7y ago

> but unless if you’re in a very specific population it doesn’t move your all cause mortality risk one iota Have you got a link to some relevant research?

village-idiot 7y ago
Sure do! I typically defer to Mark Sisson for this kind of stuff, who’s very good at linking in relevant research. https://www.marksdailyapple.com/the-evidence-continues-to-mount-against-statins/ https://www.marksdailyapple.com/the-evidence-continues-to-mo...

semenko 7y ago

Probably because most data disagree with this comment. There's a ~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL. The CTT is probably the best summary of these data: https://www.cttcollaboration.org/ https://www.cttcollaboration.org/

virtuallynathan 7y ago
> "~20% relative risk reduction in vascular events & mortality per ~40 mg/dL decrease in LDL." Is that a composite endpoint of vascular events AND mortality? From TheNNT: "It takes 5 years of daily statin therapy to achieve a 1.6% chance of avoiding a heart attack, and a 0.37% chance of avoiding a stroke. Most disappointing, statins seem unable to prevent death in this group. And most concerning, the drugs may increase diabetes, a serious and life-altering disease." (Primary Prevention) http://www.thennt.com/nnt/statins-for-heart-disease-prevention-without-prior-heart-disease-2/ http://www.thennt.com/nnt/statins-for-heart-disease-preventi...
deleted 7y ago
[deleted]
village-idiot 7y ago
That would be the same CTT that makes money from the makers of Statins and has been accused of being insufficiently transparent around their studies[0]. 0 http://www.drjohnm.org/2014/06/growing-doubt-on-statin-drugs-the-problem-of-drug-lifestyle-interaction/ http://www.drjohnm.org/2014/06/growing-doubt-on-statin-drugs...