5 ms·
It could be that it reduces mortality, but it's still above average.
by ArturSoler 7y ago
It could be that it reduces mortality, but it's still above average.
- carbocation 7y agoI agree with this conclusion. Not all mortality risk operates through cholesterol-dependent mechanisms. And even for those that do, decades of exposure to high cholesterol can’t be totally reversed by medications.
- someguydave 7y agoThat’s reasonable. Does that mean that another endpoint aside from cholesterol should be the target of control?
- carbocation 7y agoUltimately you want a readout of CAD risk, and we know that only a portion of CAD risk is attributable to LDL. We're always on the lookout for better biomarkers, but right now there isn't a comprehensive CAD biomarker (aside, perhaps, from coronary calcium - but we can't go around exposing everyone to radiation every year just to observe disease progression).
- village-idiot 7y agoLast time I’d read into it, statins didn’t move mortality numbers for most members of the population. Edit: they do decrease your risk of a heart attack a bit, but the increased incidence of cancer and diabetes actually eliminates the benefit for most users. The only people who showed any measurable reduction in mortality were non-elderly patients with a history of cardiovascular disease. https://www.marksdailyapple.com/the-evidence-continues-to-mount-against-statins/ https://www.marksdailyapple.com/the-evidence-continues-to-mo...
- carbocation 7y agoThis is a mix of outdated and simply wrong information.
- village-idiot 7y agoI’m unconvinced by your unsupported assertion.