3 ms·
Environmental Health is predatory? I am looking at https://ehjournal.biomedcentral.com/articles/10.1186/s12940-016-0117-0 https://ehjournal.biomedcentral.com/ar
by throwaway5752 7y ago
Environmental Health is predatory? I am looking at https://ehjournal.biomedcentral.com/articles/10.1186/s12940-016-0117-0 https://ehjournal.biomedcentral.com/articles/10.1186/s12940-... (first link in 8th paragraph of Bloomberg oped)
It cites a number of studies. In particular, https://pubs.acs.org/doi/10.1021/tx1001749 https://pubs.acs.org/doi/10.1021/tx1001749 ("Glyphosate-Based Herbicides Produce Teratogenic Effects on Vertebrates by Impairing Retinoic Acid Signaling") and https://www.sciencedirect.com/science/article/pii/S0300483X09003047?via%3Dihub https://www.sciencedirect.com/science/article/pii/S0300483X0... ("Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines")
I don't even know what you're talking about with Samsel and Seneff. And I can't view your link.
From the Chemical Research in Toxicology article: "A reporter gene assay revealed that GBH treatment increased endogenous retinoic acid (RA) activity in Xenopus embryos and cotreatment with a RA antagonist rescued the teratogenic effects of the GBH. Therefore, we conclude that the phenotypes produced by GBH are mainly a consequence of the increase of endogenous retinoid activity. This is consistent with the decrease of Sonic hedgehog (Shh) signaling from the embryonic dorsal midline, with the inhibition of otx2 expression and with the disruption of cephalic neural crest development."
From the Toxicology article: "First, we observed a human cell endocrine disruption from 0.5 ppm on the androgen receptor in MDA-MB453-kb2 cells for the most active formulation (R400), then from 2 ppm the transcriptional activities on both estrogen receptors were also inhibited on HepG2. Aromatase transcription and activity were disrupted from 10 ppm. Cytotoxic effects started at 10 ppm with Alamar Blue assay (the most sensitive), and DNA damages at 5 ppm."