Confidence is inextricably linked to effect size - we can be very certain that nothing major is happening, even if we're completely unsure if something is happe

Confidence is inextricably linked to effect size - we can be very certain that nothing major is happening, even if we're completely unsure if something is happening. Put more crudely, it takes a very large sample size to ascertain if bacon might increase your risk of colorectal cancer, but a very small sample size to ascertain if a bullet to the head causes brain damage.