For years I was told I was depressed and, as you described, “tried” one antidepressant after another. None of them helped with my symptoms (an otherwise health

For years I was told I was depressed and, as you described, “tried” one antidepressant after another. None of them helped with my symptoms (an otherwise healthy 20-something couldn’t get out of bed, sleeping constantly). It turned out I had lupus. I often wonder how many people who are being treated for depression have another illness entirely. I think a lot of times it’s just the best diagnosis currently available to many doctors. The drugs used to treat autoimmune diseases are “tested” by patients much the same way as antidepressants. Though there’s at least some bloodwork to guide the way. I’m optimistic technology and our rapidly growing understanding of gut bacteria will greatly improve the current trial and error approach.