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From my understanding HIV is a virus that infects immune cells and uses them to replicate. What happened is that this man had his immune system almost completel
by electromagnetic 16y ago
From my understanding HIV is a virus that infects immune cells and uses them to replicate. What happened is that this man had his immune system almost completely destroyed to defeat leukemia, and received stem cells from a donor with the mutation CCR5 known for its reduced risk of HIV infection.
Basically they destroyed the HIV's food source, and likely (at least temporarily) changed the man's new immune cells to the CCR5 variant in them that reduced the effectiveness of the HIV's ability to replicate.
Again, from my lay understanding, HIV changes its cell protein markers to avoid being attacked by immune cells. Often there are multiple HIV variants with different protein markers at one time active in a person.
IMO all but the 'newest' variant likely died of attrition, leaving one or two HIV protein marker variants that the new highly bolstered CCR5 mutant immune cells managed to latch onto and defeat.
I could be way wrong, but from my understanding this is the closest 'model' I can think of for how this would work. However, it's past my usual end-of-day so it may just be gibberish of an overtired mind.
- pak 16y agoNitpick: Viruses don't consume food for energy, they feed off of the energy metabolism of their host cell. CCR5 is a receptor that HIV binds to while entering human cells. If it is mutated in a certain rare way, HIV has a hard time entering cells, and it needs to be inside the cell to replicate. By swapping out this guy's immune system with one that has mutant CCR5, they've prevented HIV from replicating in his body.
- arghnoname 16y agoHIV is also active with glial cells. AIDS dementia complex is a direct result of HIV infection of these kinds of cells (most likely). It would be really interesting to see if there is still virus in the patient's brain, and if so, what effect it will have on him going forward.