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Whole genome sequencing on humans has only existed for 16 years (1). In 2003, the cost was prohibitive until NGS (next generation sequencing) techniques became
by dkoston 7y ago
Whole genome sequencing on humans has only existed for 16 years (1). In 2003, the cost was prohibitive until NGS (next generation sequencing) techniques became commercialized. We can definitely disagree here as 15 years of research which in my worldview is focused mostly on coding DNA and karyotyping doesn’t seem like much to draw this conclusion. There’s plenty of decades old science that has shifted or been rewritten due to the rise of new techniques related to faster computing power.
It’s quite possible that I’m biased based on the labs I’m familiar with and papers I’ve been reading. I just haven’t seen the focus that you are talking about.
1 https://www.yourgenome.org/facts/timeline-history-of-genomics https://www.yourgenome.org/facts/timeline-history-of-genomic...
- klmr 7y agoJunk DNA has already been studied before whole-genome sequencing existed, and evidence from NGS not only hasn’t overturned that research, it has largely corroborated it. And as for personal biases, I’m a staunch defender of the ENCODE research so I’m certainly not biased in favour of the concept of junk DNA.
- dkoston 7y agoInteresting. I may be biased in the other direction after reading "The Epigenetics Revolution" and "Junk DNA" by Nessa Carey. ENCODE is such an amazing project! Also, thanks for your research on non coding DNA.