Also note that most of these are spontaneous mutations, and that this paper doesn’t distinguish between correlation and causation. My take, this shoes that som

Also note that most of these are spontaneous mutations, and that this paper doesn’t distinguish between correlation and causation. My take, this shoes that something is broken it the very mechanism of DNA replication, expression, DNA repair and cell differentiation, but somehow we fail to detect those aberrant genes on late stage. So their regulation in the early development stages is when we need to look, but that’s very tough to do.