5 ms·
> Would this mean gene-therapy could potentially undo autism? Almost certainly not. Autism is caused by developmental changes. This means that any gene therapy
by klmr 7y ago
> Would this mean gene-therapy could potentially undo autism?
Almost certainly not. Autism is caused by developmental changes. This means that any gene therapy would have to start before the embryo development is even finished, i.e. in the mother’s womb. After that, it’s essentially too late. Think of it this way: Could gene therapy make an adult person taller or smaller? Despite the fact that height has a large genetic component the answer is obviously no, since skeletal growth stops after puberty.
> I believe it's now actually agreed upon that autism rates actually ARE increasing
You’re jumping the gun there. It’s plausible that there are factors that are causing an increase of autism rates (e.g. ageing parents) but so far there’s no positive evidence that this is indeed the case, or that diagnostic changes aren’t the sole reason (see https://en.wikipedia.org/wiki/Epidemiology_of_autism#Changes_with_time https://en.wikipedia.org/wiki/Epidemiology_of_autism#Changes...).
- bhouston 7y agoIt all depends on whether it is a structural thing that is established during fetal development, which can not be fixed post birth, or whether it is part of the brains's development post birth. There is a shit ton of brain development post birth -- not structural (the growth of the initial neurons) but in weeding out pathways and reinforcing certain pathways. A lot of it is based on complex feedback between activity, neurochemical releases and receptors. All of that is fair game to change post birth. Given that autism (like many other psychology labels) is a label for a diverse group of disorders which we can not fully tease apart accurately at this stage, it is likely true that some forms of autism can be treated post-birth, but others will not be.