The correct answer would be -- it depends. But in general, yes, the precise location of a gene on the chromosome matters. The chromosomes are organized in an i

The correct answer would be -- it depends. But in general, yes, the precise location of a gene on the chromosome matters. The chromosomes are organized in an intricate three dimensional structure with different levels of hierarchical organization and interacting functionally. See https://en.wikipedia.org/wiki/Topologically_associating_domain https://en.wikipedia.org/wiki/Topologically_associating_doma... and https://en.wikipedia.org/wiki/Cis-regulatory_module https://en.wikipedia.org/wiki/Cis-regulatory_module