4 ms·

Am I understanding correctly that they found they can give you this chemical and then if you experience negative things you won’t remember them (or you will but

Am I understanding correctly that they found they can give you this chemical and then if you experience negative things you won’t remember them (or you will but without negative connotations)?

danieltillett 7y ago
Yes
jazoom 7y ago
When I was doing my anaesthetics terms we used more than just propofol. We used a cocktail for various effects. Propofol to knock you out. Volatile gas to keep you under. Opioid (usually fentanyl) so you don't feel pain. Suxamethonium to relax your muscles. Benzodiazepine (e.g. midazolam) so you don't remember anything. Of course it's more complex than that since most of those also make it easier to keep you under.
- 781 7y ago
  Interesting, I believed that propofol alone is enough to not feel pain, I wasn't aware that opioids are also used at the same time.
  - ghufran_syed 7y ago
    It’s not an analgesic (drug that reduces pain), but it’s true that if you give enough propofol, you will be so unconscious, you won’t feel pain. Sometimes, anesthesiologists will give opiates so that you don’t wake up abruptly in pain, or give benzodiazepines so you feel less anxious afterwards. Depends on what they did - if you had a dislocated shoulder, the pain is much less once it has been ‘reduced’ (Put back), so you probably wouldn’t have (too) much pain, relatively speaking, once you wake up. But if someone just cut open your abdomen, you will have lots of pain on waking, so makes more sense to give some opiate beforehand, to make your wake-up ‘nicer’. Propofol also tends to lower your blood pressure a lot, so some docs feel you can get the same level of sedation with less low blood pressure by giving a bit of benzodiazepines + propofol
- deskamess 7y ago
  I am amazed we somehow found out about all these concoctions. They seem to go so far from the norm without killing you. How are they engineered in the first place? My moment was not propofol but another medicine for nausea/vomit - it worked in seconds just when I had resigned myself to throw up. I was shocked. How?
  - goldenkey 7y ago
    5-HT3 antagonism. https://en.wikipedia.org/wiki/Ondansetron https://en.wikipedia.org/wiki/Ondansetron Usually nausea is caused by the perception that your body "doesn't feel right." Serotonin is responsible for the feeling of wellbeing. Just so happens that subreceptor 3 is more about well being feeling of the body :-)
    - gurumeditations 7y ago
      So that’s why I get nauseous when I’m hungry.
- woliveirajr 7y ago
  After a surgery I temember waking up in the recovery room, suffocating (or whatever you call it when you can't breathe), asking for my regular drugs, hearing my doctor telling it was all ok during my surgery, and sleeping again.

Am I understanding correctly that they found they can give you this chemical and then if you experience negative things you won’t remember them (or you will but without negative connotations)?

danieltillett 7y ago

Yes

jazoom 7y ago

When I was doing my anaesthetics terms we used more than just propofol. We used a cocktail for various effects. Propofol to knock you out. Volatile gas to keep you under. Opioid (usually fentanyl) so you don't feel pain. Suxamethonium to relax your muscles. Benzodiazepine (e.g. midazolam) so you don't remember anything. Of course it's more complex than that since most of those also make it easier to keep you under.

781 7y ago
Interesting, I believed that propofol alone is enough to not feel pain, I wasn't aware that opioids are also used at the same time.
- ghufran_syed 7y ago
  It’s not an analgesic (drug that reduces pain), but it’s true that if you give enough propofol, you will be so unconscious, you won’t feel pain. Sometimes, anesthesiologists will give opiates so that you don’t wake up abruptly in pain, or give benzodiazepines so you feel less anxious afterwards. Depends on what they did - if you had a dislocated shoulder, the pain is much less once it has been ‘reduced’ (Put back), so you probably wouldn’t have (too) much pain, relatively speaking, once you wake up. But if someone just cut open your abdomen, you will have lots of pain on waking, so makes more sense to give some opiate beforehand, to make your wake-up ‘nicer’. Propofol also tends to lower your blood pressure a lot, so some docs feel you can get the same level of sedation with less low blood pressure by giving a bit of benzodiazepines + propofol
deskamess 7y ago
I am amazed we somehow found out about all these concoctions. They seem to go so far from the norm without killing you. How are they engineered in the first place? My moment was not propofol but another medicine for nausea/vomit - it worked in seconds just when I had resigned myself to throw up. I was shocked. How?
- goldenkey 7y ago
  5-HT3 antagonism. https://en.wikipedia.org/wiki/Ondansetron https://en.wikipedia.org/wiki/Ondansetron Usually nausea is caused by the perception that your body "doesn't feel right." Serotonin is responsible for the feeling of wellbeing. Just so happens that subreceptor 3 is more about well being feeling of the body :-)
  - gurumeditations 7y ago
    So that’s why I get nauseous when I’m hungry.
woliveirajr 7y ago
After a surgery I temember waking up in the recovery room, suffocating (or whatever you call it when you can't breathe), asking for my regular drugs, hearing my doctor telling it was all ok during my surgery, and sleeping again.