3 ms·

Depends on how random the group is and how much confidence you want out of such study.

• sterwill 7y ago
  And how great the effect is. If you recruited only 5 healthy humans at random and administered a new drug and 100% of them died instantly, you can probably make some useful predictions.
  • YeGoblynQueenne 7y ago
    Yes, and the effect was tiny. See the caption in figure 2 for a summary: Scores (percentage) for each story per group: group A (n = 25 participants) reactivated mean (SEM) = 53.49 (2.29); nonreactivated mean = 59.20 (2.60); group B (n = 24 participants) reactivated mean = 59.52 (1.97); nonreactivated mean = 61.19 (2.11). That's 6.03% difference between the groups on reactivated means and 2% on the nonreactivated means. Each group was 25 people. What's the predictive power of this? What's the explanatory power? What did we learn? That 25 people reacted a little differently than 25 other people on a test after the same drug was administered and some more time elapsed between the times when the two groups took the tests. There's nothing to see here. Edit: Btw, both groups received endoscopy and midazolam or phenylpiperidine derivatives- so not only the effect measured was small it was also not possible to clearly attribute it to propofol, rather than the endoscopy or the additional drugs administered.
    • sterwill 7y ago
      My comment used a hypothetical toxicity study where 100% of people died instantly as an example of a very large effect size. It did not address the Propofol sedation study.