Yes, you just need to set rotation in your software. For RPi it is trivial to do so. I have done this in practice, wires go up rather than down, which could be

Yes, you just need to set rotation in your software. For RPi it is trivial to do so. I have done this in practice, wires go up rather than down, which could be argued to be even better as it can't rub against your cheek. I use Vufine's Pro mount, which has clips/ties for wires holding, so it doesn't matter which way wires go out of the device, forces balance doesn't change as you turn your head.