5 ms·

What reproducibility are you referring to? LSD was marketed as a medicine under the name Delysid for over 10 years mid-century but only afterward did it gain a

by doitLP 7y ago

What reproducibility are you referring to? LSD was marketed as a medicine under the name Delysid for over 10 years mid-century but only afterward did it gain a schedule 1 classification after it was declared to have no medical uses.

leoh 7y ago
LSD almost certainly has medical value when administered properly; viz. https://en.m.wikipedia.org/wiki/Spring_Grove_Experiment?wprov=sfti1 https://en.m.wikipedia.org/wiki/Spring_Grove_Experiment?wpro.... It was banned in spite of its medical potential, not because of it.
- doitLP 7y ago
  Those studies were pretty terribly done, with no control and other confounding factors. Maybe indicative of more study but nowhere near substantial or reproducible. Edit: Replying with a 45 year-old study with extremely low scientific merit is silly especially on HN. I was asking specifically for references to the reproducibility op mentioned.
  - pg_is_a_butt 7y ago
    Except for the control of literally everyone else who wasn't tripping their balls off.
  - worik 7y ago
    Modern studies: For the terminally ill: https://www.independent.co.uk/news/people/professor-david-nutt-why-i-think-the-terminally-ill-should-take-lsd-10092213.html https://www.independent.co.uk/news/people/professor-david-nu... Treating depression: https://www.ft.com/content/2c4121de-c5d6-11e5-808f-8231cd71622e https://www.ft.com/content/2c4121de-c5d6-11e5-808f-8231cd716... https://www.theguardian.com/science/2015/mar/05/psychedelic-drugs-like-lsd-could-be-used-to-treat-depression-study-suggests https://www.theguardian.com/science/2015/mar/05/psychedelic-... Microdosing: https://psyarxiv.com/gk4jd/ https://psyarxiv.com/gk4jd/
    - doitLP 7y ago
      Thank you
      - e1g 7y ago
        If you're interested in the topic of medical history of psychedelics, I would highly recommend "How to Change Your Mind" by Michael Pollan of nutrition fame. He decides to experiment with psychedelics for the first time in his late 50s, and the book describes his journey as well as changes in personal philosophy. He masterfully combines history lessons and personal experiences to paint an informative picture of where this topics might head. In NYC, for example, it is now perfectly legal to get a heavy dosage of ketamine administered by Columbia University doctors (see https://www.columbiadoctors.org/specialties/psychiatry-psychology/our-services/ketamine-program https://www.columbiadoctors.org/specialties/psychiatry-psych...)
        atomical 7y ago
        It's perfectly legal to get ketamine from any doctor! The program you linked costs $650/infusion. > A typical case would be 8-12 infusions over 4-6 weeks. That's $7,800 for a month of treatment. That's a lot of money when considering that ketamine is not a cure and the patient will need future treatments. I'm taking 250mg sublingual every day and paying ~$3000/year. Most of the cost is taxis, planes, and shipping because I'm out of state and have to fly in to see my doctor. If I lived in Maryland the cost would be much lower. Also, if infusion clinic docs weren't bankrupting patients by picking the most expensive (read: lucrative) ROA the cost would be much cheaper.
bookofjoe 7y ago
http://www.drsessa.com/wp-content/uploads/2014/09/Delysid-1964-Catalogue.pdf http://www.drsessa.com/wp-content/uploads/2014/09/Delysid-19...
- matthewwiese 7y ago
  That document you linked is fascinating. It's especially relevant to me because I'm currently taking a class through my university's pharmacy department on drug discovery and development in the pharmaceutical industry. Just last week I wrote about PCP's origins as an aesthetic (similar to ketamine). This[1] is a good source on the topic. Do you happen to know of other documents in a vein similar to the LSD one you linked? Pharmacology is one of many bizarre topics I endeavor to understand in my free time (this weird thing called "programming" also happens to be one). [1]: https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.1620 https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.1620
  - bookofjoe 7y ago
    Matthew, that document appeared on the first page of a Google search for Delysid, where it was the first result of 187,000 [https://www.google.com/search?newwindow=1&hl=en&source=hp&ei=80vnXI61IKWxggfByJCIDQ&q=Delysid&oq=Delysid&gs_l=psy-ab.12..0l10.2959.2959..7653...0.0..0.283.497.2-2......0....2j1..gws-wiz.....0._NMD0NM9CTM https://www.google.com/search?newwindow=1&hl=en&source=hp&ei...]. I'd never heard of it until seeing the name in the comment I replied to. It's a one-off as far as my having others like it to send on. FWIW, as a retired neurosurgical anesthesiologist (38 years experience/age 70) on three antidepressants (lithium/Wellbutrin/Paxil) for life after four severe episodes of major depression, I found it (the document) as fascinating as you did. P.S. This: https://mattwie.se/ https://mattwie.se/ is very cool.
yboris 7y ago
LSD cured alcoholism with high success rate.
- raptorraver 7y ago
  As an anecdote: the founder of AA suggested LSD as a treatment to alcohol addiction. https://www.theguardian.com/science/2012/aug/23/lsd-help-alcoholics-theory https://www.theguardian.com/science/2012/aug/23/lsd-help-alc...

by doitLP 7y ago

leoh 7y ago

LSD almost certainly has medical value when administered properly; viz. https://en.m.wikipedia.org/wiki/Spring_Grove_Experiment?wprov=sfti1 https://en.m.wikipedia.org/wiki/Spring_Grove_Experiment?wpro.... It was banned in spite of its medical potential, not because of it.

doitLP 7y ago
Those studies were pretty terribly done, with no control and other confounding factors. Maybe indicative of more study but nowhere near substantial or reproducible. Edit: Replying with a 45 year-old study with extremely low scientific merit is silly especially on HN. I was asking specifically for references to the reproducibility op mentioned.
- pg_is_a_butt 7y ago
  Except for the control of literally everyone else who wasn't tripping their balls off.
- worik 7y ago
  Modern studies: For the terminally ill: https://www.independent.co.uk/news/people/professor-david-nutt-why-i-think-the-terminally-ill-should-take-lsd-10092213.html https://www.independent.co.uk/news/people/professor-david-nu... Treating depression: https://www.ft.com/content/2c4121de-c5d6-11e5-808f-8231cd71622e https://www.ft.com/content/2c4121de-c5d6-11e5-808f-8231cd716... https://www.theguardian.com/science/2015/mar/05/psychedelic-drugs-like-lsd-could-be-used-to-treat-depression-study-suggests https://www.theguardian.com/science/2015/mar/05/psychedelic-... Microdosing: https://psyarxiv.com/gk4jd/ https://psyarxiv.com/gk4jd/
  - doitLP 7y ago
    Thank you
    - e1g 7y ago
      If you're interested in the topic of medical history of psychedelics, I would highly recommend "How to Change Your Mind" by Michael Pollan of nutrition fame. He decides to experiment with psychedelics for the first time in his late 50s, and the book describes his journey as well as changes in personal philosophy. He masterfully combines history lessons and personal experiences to paint an informative picture of where this topics might head. In NYC, for example, it is now perfectly legal to get a heavy dosage of ketamine administered by Columbia University doctors (see https://www.columbiadoctors.org/specialties/psychiatry-psychology/our-services/ketamine-program https://www.columbiadoctors.org/specialties/psychiatry-psych...)
      - atomical 7y ago
        It's perfectly legal to get ketamine from any doctor! The program you linked costs $650/infusion. > A typical case would be 8-12 infusions over 4-6 weeks. That's $7,800 for a month of treatment. That's a lot of money when considering that ketamine is not a cure and the patient will need future treatments. I'm taking 250mg sublingual every day and paying ~$3000/year. Most of the cost is taxis, planes, and shipping because I'm out of state and have to fly in to see my doctor. If I lived in Maryland the cost would be much lower. Also, if infusion clinic docs weren't bankrupting patients by picking the most expensive (read: lucrative) ROA the cost would be much cheaper.

bookofjoe 7y ago

http://www.drsessa.com/wp-content/uploads/2014/09/Delysid-1964-Catalogue.pdf http://www.drsessa.com/wp-content/uploads/2014/09/Delysid-19...

matthewwiese 7y ago
That document you linked is fascinating. It's especially relevant to me because I'm currently taking a class through my university's pharmacy department on drug discovery and development in the pharmaceutical industry. Just last week I wrote about PCP's origins as an aesthetic (similar to ketamine). This[1] is a good source on the topic. Do you happen to know of other documents in a vein similar to the LSD one you linked? Pharmacology is one of many bizarre topics I endeavor to understand in my free time (this weird thing called "programming" also happens to be one). [1]: https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.1620 https://onlinelibrary.wiley.com/doi/abs/10.1002/dta.1620
- bookofjoe 7y ago
  Matthew, that document appeared on the first page of a Google search for Delysid, where it was the first result of 187,000 [https://www.google.com/search?newwindow=1&hl=en&source=hp&ei=80vnXI61IKWxggfByJCIDQ&q=Delysid&oq=Delysid&gs_l=psy-ab.12..0l10.2959.2959..7653...0.0..0.283.497.2-2......0....2j1..gws-wiz.....0._NMD0NM9CTM https://www.google.com/search?newwindow=1&hl=en&source=hp&ei...]. I'd never heard of it until seeing the name in the comment I replied to. It's a one-off as far as my having others like it to send on. FWIW, as a retired neurosurgical anesthesiologist (38 years experience/age 70) on three antidepressants (lithium/Wellbutrin/Paxil) for life after four severe episodes of major depression, I found it (the document) as fascinating as you did. P.S. This: https://mattwie.se/ https://mattwie.se/ is very cool.

yboris 7y ago

LSD cured alcoholism with high success rate.

raptorraver 7y ago
As an anecdote: the founder of AA suggested LSD as a treatment to alcohol addiction. https://www.theguardian.com/science/2012/aug/23/lsd-help-alcoholics-theory https://www.theguardian.com/science/2012/aug/23/lsd-help-alc...