I disagree with some of your premise, but agree in general. I sort of think of this as a "science vs engineering" problem. Science can be patient for the correc

I disagree with some of your premise, but agree in general. I sort of think of this as a "science vs engineering" problem. Science can be patient for the correct answer, but engineering needs a good-enough model of the problem to make something work today. Enter the DSM, which is on the engineering side of the aisle. It provides common terminology but is almost certainly lumping too many things together. So if your treatment doesn't help many different problems that look sort of similar all at the same time, it shows no effect at all. Which doesn't mean it won't do a great job with one of two of those narrower subtypes. This guy does some great work on the topic: https://eiko-fried.com/the-replication-crisis-hits-psychiatry-no-candidate-genes-for-depression/ https://eiko-fried.com/the-replication-crisis-hits-psychiatr...