This is a meta-analysis of 13 studies. The rate change is certainly real, but remember this wasn't a study targeting that characteristic. I also didn't read the

This is a meta-analysis of 13 studies. The rate change is certainly real, but remember this wasn't a study targeting that characteristic. I also didn't read the studies mentioned, so I don't know what time frame the change appears over (is it over a patients lifetime? a year? who knows?). Also, all of the patients were Asian, which could also have some effect, and they were all lean. As far as I'm aware, these aren't characteristics of those who usually receive recommendations for regularly taking aspirin. Meanwhile, heart disease kills nearly a quarter of Americans. > Results The search identified 13 randomized clinical trials of low-dose aspirin use for primary prevention, enrolling 134 446 patients. Pooling the results from the random-effects model showed that low-dose aspirin, compared with control, was associated with an increased risk of any intracranial bleeding (8 trials; relative risk, 1.37; 95% CI, 1.13-1.66; 2 additional intracranial hemorrhages in 1000 people), with potentially the greatest relative risk increase for subdural or extradural hemorrhage (4 trials; relative risk, 1.53; 95% CI, 1.08-2.18) and less for intracerebral hemorrhage and subarachnoid hemorrhage. Patient baseline features associated with heightened risk of intracerebral hemorrhage with low-dose aspirin, compared with control, were Asian race/ethnicity and low body mass index. > Conclusions and Relevance Among people without symptomatic cardiovascular disease, use of low-dose aspirin was associated with an overall increased risk of intracranial hemorrhage, and heightened risk of intracerebral hemorrhage for those of Asian race/ethnicity or people with a low body mass index.