Also, this technology is brand new. I mean, brand new. Single-cell RNA seq is only a few years old; single-nuclear is even newer. There are significant problems

Also, this technology is brand new. I mean, brand new. Single-cell RNA seq is only a few years old; single-nuclear is even newer. There are significant problems with analyzing this data, mostly related to the necessity to correct statistically between samples to remove batch effects before you can cross-compare. This is very, very hard and in general we are bad at it. I would say we can't really do it yet, and so experiments purporting to show differences between patients are likely to be the result of statistical artifacts, and not actual biological differences.