That is a really neat paper. > Successful replacement codons tended to conserve local ribosomal binding site-like motifs and local mRNA secondary structure, so

That is a really neat paper. > Successful replacement codons tended to conserve local ribosomal binding site-like motifs and local mRNA secondary structure, sometimes at the expense of amino acid identity. Based on these observations, we empirically defined metrics for a multidimensional “safe replacement zone” (SRZ) within which alternative codons are more likely to be viable.