I am not an expert (my biology degree is 30 years old) but generally the idea is that, if you create an artificial genome, you pop it it into a similar cell, wh

I am not an expert (my biology degree is 30 years old) but generally the idea is that, if you create an artificial genome, you pop it it into a similar cell, which has previously had its native DNA removed) giving it the necessary machinery to express itself etc. Obviously, you're creating a hybrid, but over time the effect of the original host cell's makeup will diminish.