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I think the meaning of "synthetic genome" here is "synthesized in vitro", not "100% artificially engineered sequence".
by Reelin 7y ago
I think the meaning of "synthetic genome" here is "synthesized in vitro", not "100% artificially engineered sequence".
- rorykoehler 7y agoI'm having difficulty understanding how a 100% artificially engineered sequence would come about? What is the raw material that would be used to start something like this?
- Angostura 7y agoI am not an expert (my biology degree is 30 years old) but generally the idea is that, if you create an artificial genome, you pop it it into a similar cell, which has previously had its native DNA removed) giving it the necessary machinery to express itself etc. Obviously, you're creating a hybrid, but over time the effect of the original host cell's makeup will diminish.
- hobofan 7y agoVery much depends what one would consider a "100% artificially engineered sequence". You could possibly swap out GATC for a different set of bases. You could also replace DNA with XNA. There are a whole lot exotic avenues for "artificially engineered", with each of them coming with its own mountain of challenges.