I doubt that's the only reason but according to this table [0], AGC triplets are 2x more prevalent than UGC in that bacteria. Edit: this the frequency of that

I doubt that's the only reason but according to this table [0], AGC triplets are 2x more prevalent than UGC in that bacteria. Edit: this the frequency of that codon being used o the genome sequence. But the assumption could be that it is also preferably produced as a t-RNA so it can replicate its genome efficiently. It's more likely that they have introduced errors, or non-preferred patterns, which affect the number of replication forks and stall the replication machinery. [0] https://www.kazusa.or.jp/codon/cgi-bin/showcodon.cgi?species=83333 https://www.kazusa.or.jp/codon/cgi-bin/showcodon.cgi?species...