You don't need to try to induce it in humans, you want to create treatments that work. In this case the study in rats provides an interesting hunch, that food

You don't need to try to induce it in humans, you want to create treatments that work. In this case the study in rats provides an interesting hunch, that food restriction and excessive exercise seem linked. Then you can certainly run a trial where you either eliminate exercise or not, and see if it makes a difference.