This sounds an awful lot like the problem of modelling the turbulent reacting flow inside a rocket engine. SpaceX did some neat work on this and presented it at

This sounds an awful lot like the problem of modelling the turbulent reacting flow inside a rocket engine. SpaceX did some neat work on this and presented it at a GPU conference. They did some unconventional things with the GPU, allowing variable-resolution modeling. Previously, it had not been possible to accurately model an engine because the scale required to cover the whole engine could not express the detail of the microphysics.