Personally, I prefer ISO- the Big Enter bothers me because it removes one spot that my pinky could be pushing buttons from, and so feels less efficient. Mind y

Personally, I prefer ISO- the Big Enter bothers me because it removes one spot that my pinky could be pushing buttons from, and so feels less efficient. Mind you, when programming, I touch type with my right hand translated over a row- so instead of [J][K][L][;] it'd be [K][L][;]['] and my pinky is just all over the place. I do see why people like ANSI, but it's probably just a nature / nurture thing.