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You can be genetically blessed. The "gene variant ‘p.Tyr362His’" let's one get by on less than 5 hrs of sleep. See: Margaret Thatcher. A friend of mine that got

by wolf7 7y ago

You can be genetically blessed. The "gene variant ‘p.Tyr362His’" let's one get by on less than 5 hrs of sleep. See: Margaret Thatcher. A friend of mine that got 2 Bachelors and 2 Masters degrees in 4 years might've had that, though he said he just got used to the lack of sleep. source: https://www.telegraph.co.uk/news/science/science-news/11006181/Thatcher-gene-is-key-to-needing-less-sleep.html https://www.telegraph.co.uk/news/science/science-news/110061...

Maximus9000 7y ago
If I recall correctly, the odds of you having that gene variant are somewhere in the realm of getting struck by lightning. Also, Margaret Thatcher went on to develop Alzheimers. https://www.nih.gov/news-events/nih-research-matters/sleep-deprivation-increases-alzheimers-protein https://www.nih.gov/news-events/nih-research-matters/sleep-d...
013a 7y ago
Its kind of amazing to me that we haven't heard more, or maybe aren't seeing more, research into drugs or therapy which could reduce the amount of sleep people need. We'd be talking about the greatest boon to global productivity in the history of mankind, likely singularly more impactful than any other technology we've ever developed. The company which develops it could sell it for literally any price and they'd have people scrambling for it. Not suggesting its easy, or possible, but its just surprising to me that I don't hear anyone talking about it. Modafinil might be the closest I've seen but its obviously not for long-term use. Google/Alphabet is pouring hundreds of millions into Calico to fight aging, but fighting Sleep feels like a much easier target that could have much more impactful consequences (extending life from 80 to 100 isn't nearly as interesting as giving a ~30 year old even 10% more time with their younger body and mind). And once its solved we'll inevitably flip into a dystopian society where the poor either can't afford the drug and thus become poorer, or are the only ones taking it because they now have to work 22 hours a day, but Hey, we'll worry about that when we get there.
- pugz 7y ago
  Why do you say modafinil is not for long-term use? I take it 7 times a week, have done so for years and my doctor tells me it's likely that I will be taking it as long as I need it (in my case: a lifetime, as it's treating a chronic condition).

by wolf7 7y ago

Maximus9000 7y ago

If I recall correctly, the odds of you having that gene variant are somewhere in the realm of getting struck by lightning. Also, Margaret Thatcher went on to develop Alzheimers. https://www.nih.gov/news-events/nih-research-matters/sleep-deprivation-increases-alzheimers-protein https://www.nih.gov/news-events/nih-research-matters/sleep-d...

013a 7y ago

Its kind of amazing to me that we haven't heard more, or maybe aren't seeing more, research into drugs or therapy which could reduce the amount of sleep people need. We'd be talking about the greatest boon to global productivity in the history of mankind, likely singularly more impactful than any other technology we've ever developed. The company which develops it could sell it for literally any price and they'd have people scrambling for it. Not suggesting its easy, or possible, but its just surprising to me that I don't hear anyone talking about it. Modafinil might be the closest I've seen but its obviously not for long-term use. Google/Alphabet is pouring hundreds of millions into Calico to fight aging, but fighting Sleep feels like a much easier target that could have much more impactful consequences (extending life from 80 to 100 isn't nearly as interesting as giving a ~30 year old even 10% more time with their younger body and mind). And once its solved we'll inevitably flip into a dystopian society where the poor either can't afford the drug and thus become poorer, or are the only ones taking it because they now have to work 22 hours a day, but Hey, we'll worry about that when we get there.

pugz 7y ago
Why do you say modafinil is not for long-term use? I take it 7 times a week, have done so for years and my doctor tells me it's likely that I will be taking it as long as I need it (in my case: a lifetime, as it's treating a chronic condition).