> Actually developing resistance against bacteriophages requires such invasive changes that most bacteria that develop it lose resistance against anti-biotics

> Actually developing resistance against bacteriophages requires such invasive changes that most bacteria that develop it lose resistance against anti-biotics It requires some huge changes, sure. However, MRSA exists because Staph was able to adapt to be resistant to multiple antibiotics at the same time. There is no reason to assume that it could not adapt to become resistant to the phage used as well as some of the most used antibiotics.