The biggest issue if we can make it non-transmissible (which we are already to that point for first-world serodiscordant couples, to a large degree) is getting

The biggest issue if we can make it non-transmissible (which we are already to that point for first-world serodiscordant couples, to a large degree) is getting it to the third world, where not only is there no money for this, but there's some pretty vile things going on that worsen the spread.