Certainly, people should review anything they plan on taking with their doctor. Berberine is well tested (about 3000 years of medical use). It wasn't until th

Certainly, people should review anything they plan on taking with their doctor. Berberine is well tested (about 3000 years of medical use). It wasn't until the last decade or so they found it had the same use as Metformin. Apparently metabolic syndrome is less of an issue in China? They mostly used it for gut infections and as a clothing dye. The most common interaction id diarrhea and cramping from diarrhea. (same as Metformin) It can also cause sweating and low blood sugar.