3 ms·
This is cool, but would be significantly cooler if they did some kind of biological follow up. Perhaps getting their model to output an "ideal" sequence for a d
by shpongled 7y ago
This is cool, but would be significantly cooler if they did some kind of biological follow up. Perhaps getting their model to output an "ideal" sequence for a desired enzymatic function and then swapping that domain into an existing protein lacking the new function.
- inciampati 7y agoBingo. That would be really interesting. And useful. There are probably already enzymes in this data set that have measurements of their behavior. Could this modelling approach be coaxed to find the one with the highest processivity? Or do we need more labeled data?
- shpongled 7y agoI'm sure they have a bunch of enzymes in their dataset for which kinetic measurements have been published. Another interesting follow up study would attempting to improve kinetic behavior. They could, for instance, analyze some of the catalytically perfect enzymes out there (TIM, SOD, catalase, etc) and see if the model could project improvements onto existing orthogonal protein classes.
- jerven 7y agoNot in a structured way that is easily useable. Swiss-Prot has most of this data but it is not quite normalized in units. If you did this annoying work I would like to talk to you so we can plug it into Swiss-Prot.