2 ms·
>I’d say the opposite is true there are many available studies on dietary inflammation (ie chronic inflammation) and depression being linked. We still don't ha
by jdietrich 8y ago
>I’d say the opposite is true there are many available studies on dietary inflammation (ie chronic inflammation) and depression being linked.
We still don't have any real idea of the causal directionality between inflammation and depression. The best available evidence (and the best available evidence is very weak) suggests that depression causes inflammation rather than vice-versa; depressive illness predicts levels of inflammation markers, but inflammation markers do not predict depression.
Some antidepressant drugs do have anti-inflammatory properties, but the reverse is not necessarily true. Several clinical trials of anti-inflammatory drugs have failed to show efficacy in the treatment of depression.
Presently, the inflammatory hypothesis is distinctly hypothetical; while some basic neurobiological research in mice support it, we have no real clinical evidence to suggest that reducing inflammation has any meaningful effect on depressive illnesses.
https://www.sciencedirect.com/science/article/pii/S0889159109001135 https://www.sciencedirect.com/science/article/pii/S088915910...
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(05)00866-8/fulltext https://www.biologicalpsychiatryjournal.com/article/S0006-32...
https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2444 https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2444