3 ms·

>The evidence linking diet and depression is really very limited. I’d say the opposite is true there are many available studies on dietary inflammation (ie chr

>The evidence linking diet and depression is really very limited. I’d say the opposite is true there are many available studies on dietary inflammation (ie chronic inflammation) and depression being linked. See the inflammatory hypothesis of depression, also interesting is data is beginning to reveal a link between inflammation and the 1/3 of patients who do not respond to antidepressant medications. Generally when working antidepressants have an anti inflammatory effects. It should also be noted that the diets mentioned Keto/carnivore/vegan all generally emphasize the removal of inflammatory foods (ie refined sugars, refined carbs, fried foods, artificial trans fats, etc...).

jdietrich 7y ago
>I’d say the opposite is true there are many available studies on dietary inflammation (ie chronic inflammation) and depression being linked. We still don't have any real idea of the causal directionality between inflammation and depression. The best available evidence (and the best available evidence is very weak) suggests that depression causes inflammation rather than vice-versa; depressive illness predicts levels of inflammation markers, but inflammation markers do not predict depression. Some antidepressant drugs do have anti-inflammatory properties, but the reverse is not necessarily true. Several clinical trials of anti-inflammatory drugs have failed to show efficacy in the treatment of depression. Presently, the inflammatory hypothesis is distinctly hypothetical; while some basic neurobiological research in mice support it, we have no real clinical evidence to suggest that reducing inflammation has any meaningful effect on depressive illnesses. https://www.sciencedirect.com/science/article/pii/S0889159109001135 https://www.sciencedirect.com/science/article/pii/S088915910... https://www.biologicalpsychiatryjournal.com/article/S0006-3223(05)00866-8/fulltext https://www.biologicalpsychiatryjournal.com/article/S0006-32... https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2444 https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2444

jdietrich 7y ago

>I’d say the opposite is true there are many available studies on dietary inflammation (ie chronic inflammation) and depression being linked. We still don't have any real idea of the causal directionality between inflammation and depression. The best available evidence (and the best available evidence is very weak) suggests that depression causes inflammation rather than vice-versa; depressive illness predicts levels of inflammation markers, but inflammation markers do not predict depression. Some antidepressant drugs do have anti-inflammatory properties, but the reverse is not necessarily true. Several clinical trials of anti-inflammatory drugs have failed to show efficacy in the treatment of depression. Presently, the inflammatory hypothesis is distinctly hypothetical; while some basic neurobiological research in mice support it, we have no real clinical evidence to suggest that reducing inflammation has any meaningful effect on depressive illnesses. https://www.sciencedirect.com/science/article/pii/S0889159109001135 https://www.sciencedirect.com/science/article/pii/S088915910... https://www.biologicalpsychiatryjournal.com/article/S0006-3223(05)00866-8/fulltext https://www.biologicalpsychiatryjournal.com/article/S0006-32... https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2444 https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2444