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Blood platelets activated during exercise increase neurogensis: mouse study
- joss82 8y ago... in mice.
- DoreenMichele 8y ago...that are running the equivalent of a marathon every night.
- killjoywashere 8y ago... never mind the other potentially adverse effects of platelet activation. Like, you know, clotting.
- gyaniv 8y agoThat's the mentioned exercise.
- DoreenMichele 8y agoYes, it is. But it's quite a lot more exercise than most humans are going to engage in. I spent a few years walking several hours a day. I was unemployed and homeless at the time. It was very beneficial to my health, but I hesitate to "recommend" it because I know what most people will tell me: they can't spend that kind of time walking every day, even if it could potentially save their life.
- Pahr3yah 8y agoyou can install a treadmill under a standing desk and walk while you work.
- mfatica 8y agoI've tried this and for usual tasks it's fine but for tasks that require deep concentration it was inhibiting cognition
- meko 8y agoThat was exactly my experience too. Programming + standing was neigh impossible.
- astura 8y agoIt's incredibly distracting, I couldn't imagine trying to work on a treadmill, I can't even manage to play turn based RPGs on the treadmill on the lowest setting. The only treadmill activities that have worked for me are TV and podcasts.
- TheSpiceIsLife 8y agoI don't know how they can claim to make this comparison. Do an image search for mouse skeleton and compare to dog skeleton. These creatures are hyper specialised to run pretty much nonstop all day every day, as evidenced by the fact that lab mice will voluntarily run 10km when present with a mouse wheel and no prior training. Human running is bound to be way more laborious. The comparison is nonsense. I agree with your broader point though. Edit to add: My previous pup, a Border Collie x German Shorthaired Pointed, after only five introductory sessions, would voluntarily get on the treadmill we had set up for her. There is something inherently different about these creatures. One of my pet theories of why they don't live as long is because they're brains are hardwired to make them act like they're on MDMA and amphetamine all the time.
- xattt 8y agoYour suggestion that exercise is more laborious would suggest that smaller amounts of exertion would be sufficient in achieving the same effect.
- TheSpiceIsLife 8y agoYes, that's my claim.
- _Microft 8y agoYou might find this interesting: most mammals have a maximum number of heartbeats of about 1 billion in their life and the smaller an animal, the faster their heart beats. So the faster the heart beats, the shorter their life is. Why this is a rule, I have no idea. Humans are an exception to this with approximately 4 billion heartbeats possible in life. It is only mentioned in the german Wikipedia [0] but not in the english. [0] https://de.wikipedia.org/wiki/Herzfrequenz#Herzfrequenz_bei_Tieren https://de.wikipedia.org/wiki/Herzfrequenz#Herzfrequenz_bei_... Edit: citations 5 and 6 might be a good starting point to delve into this.
- TheSpiceIsLife 8y agoI’ve come across this idea before. I wonder how active a person would have to be over a life time compared to an inactive person to run out or heart beats and die before the inactive person succumbed to the maladies of the lazy.
- dang 8y agoOk, we've put some mice in the title above.
- gvand 8y agoI wonder if someone has ever applied some of these studies (that sometimes show an increased lifespan from 30% to 60%) with the sole intent to obtain a super mouse with incredibly long lifespan and some other incredible characteristics.
- JamesBarney 8y agoI think you'll be interested in https://en.m.wikipedia.org/wiki/Methuselah_Foundation https://en.m.wikipedia.org/wiki/Methuselah_Foundation In 2003, the organization was made public as the Methuselah Foundation at the 32nd Annual Meeting of the American Aging Association,[7] where they awarded the first Methuselah Mouse Prize to Andrej Bartke for his work on mice that lived the equivalent of 180 human years.
- napo 8y ago(There's a typo on HN's title, the last "e" is missing in neurogenesis)
- thesz 8y agoWhat is interesting is to see effect size. For example, exercise would produce huge effect in blood content that transports oxygen and relatively small effect on brain-derived neurotrophic factor. For humans BDNF measures in 39 nanogramms per millilitre [1] - it is highly dissolved. I seriously doubt that masspectrometry can handle this. [1] https://www.hindawi.com/journals/bmri/2013/901082/ https://www.hindawi.com/journals/bmri/2013/901082/ Also, [2] - the BDNF level for sprint runners is more than 5 (five) times higher than of sedentiary people for Olympic team members. [2] https://www.researchgate.net/publication/51658551_Increased_basal_plasma_brain-derived_neurotrophic_factor_levels_in_sprint_runners https://www.researchgate.net/publication/51658551_Increased_... I guess the ability to run marathon every night can easily put one into Olympic team. ;)
- shishy 8y agoThe study suggests that platelet 4, which is elevated when running, influences neurogenesis. Do we know if platelet 4 is only increased during running? What about weight lifting for example?
- anu7df 8y agoWeight lifting mice! Now that I would like to see. Ethics be damned
- mises 8y agoIt's not a bad question. Does it have to be cardio? Isometric exercise? I've heard a lot of buzz about high-impact interval training; does that work? The questions do need answering, and though mice may not provide the full answer, they can still provide some information, and maybe enough for more research to be funded.
- basetop 8y agoThe neverending mouse studies that rarely apply for humans. "Misleading mouse studies waste medical resources" https://www.nature.com/news/misleading-mouse-studies-waste-medical-resources-1.14938 https://www.nature.com/news/misleading-mouse-studies-waste-m... "Why animal studies are often poor predictors of human reactions to exposure" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746847/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746847/ "Drugs That Work In Mice Often Fail When Tried In People" https://www.npr.org/sections/health-shots/2017/04/10/522775456/drugs-that-work-in-mice-often-fail-when-tried-in-people https://www.npr.org/sections/health-shots/2017/04/10/5227754... Not sure what the answer is to human medical testing and research since experimenting on humans is unethical. But mice shouldn't stand in for humans for human research since mice and humans are very different. I wonder how scientists in the future will look upon using mice for human medical research.
- DanBC 8y agoMy current favourite twitter account is https://twitter.com/justsaysinmice https://twitter.com/justsaysinmice
- pazimzadeh 8y agoYes, that's a great way of staying on the cutting edge of basic science in mammals.
- superpermutat0r 8y agoIt's absolutely idiotic. There's no scientific basis for testing these kinds of stuff on animals yet somehow it is still being done. Also a nice source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902221/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902221/
- pazimzadeh 8y agoLet's not get carried away. There is plenty of scientific basis for testing on other mammals. Hell, most of our knowledge of genetics comes from work done on fruit flies. Many key immune pathways like TLR (Toll-Like Receptors) would have come to our attention later if it wasn't for research in fruit flies. Obviously though, we have lots more in common with mice than with flies. Hence, it's worth it. The problem you're describing has more to do with journalists over-hyping scientific results than the utility of said results.
- hourislate 8y agoMy take away from all the 1000's of articles and studies I've read on health is: Eat real food (Not processed. (ex: eggs, fish, meat, fowl, vegetables, some fruit)) and not so much. Don't smoke cigarettes or drink alcohol. Exercise daily (even if it's just a brisk walk for 30 mins). Find time to meditate (rest your mind) for a few minutes a day, even day dreaming for 5-10 minutes is great. Try to get a good nights sleep (approx 7 hours for an adult). Try to Fast at least 12-16 hours a day (typically over night while you sleep, 6 pm to 10 am). Seems like it should be easy but somehow we still make it complicated.
- 52-6F-62 8y agoBecause, as simple as that advice might be, it's not all there is to it—and we don't live in a vacuum. All things in moderation—including moderation. My takeaway from many mental health discussions has been to: * Look after your body/love yourself by being good to your body (this includes your takeaways) * Try to see things from others' perspectives * Relax and just have a damned beer if you want a damned beer. It's not all that heavy—it's life and life only. (just an aside/tangent: I'm not for fasting in the way you've prescribed. From what I understand about it is that it won't hurt you, but it doesn't gain you anything either unless you're having difficulty managing your caloric budget)
- magnamerc 8y agoFasting has several benefits not related to caloric intake. It honestly has too many to list here, suffice to say that you should look into it a bit more.
- magnamerc 8y agoI'd agree with all points, but you should really aim for a non-negotiable 8 hours of continuous sleep time. At 7 hours total sleep time, you're still in a sleep deficit as an adult. As we age, we get less and less stage 3 and 4 deep sleep which is responsible for clearing tau and beta amyloid through the meningeal lymphatic drainage system (and the glymphatic system). Alzeihmers and related dementia are disorders that arise due to impaired sleep, either through sleep deficits, or from disrupted sleep due to sleep apnea. If you think about it, you can go without food and water for long-ish periods of time, but you can't go without sleep longer than a week or maybe two before you have irreparable damage. From an evolutionary perspective, this seems crazy since you're in your most vulnerable state and you're missing out on 8 hours of food foraging, or procreation. Obviously evolution has found that sleep is absolutely necessary for all living organisms. It's by far the most important aspect of living healthy lives, but it's the least appreciated in Western society.
- bigDICK 8y agoThere are so many things that cause neurogenesis. It's not really that impressive unless the effect is strong. In that case though it could be dangerous or not optimal to intelligence.