Well, there is more to plaque and thus caries than just one enzyme no matter how much it gets hyped up. I've done quite a bit of research on this and the short

Well, there is more to plaque and thus caries than just one enzyme no matter how much it gets hyped up. I've done quite a bit of research on this and the short answer is that it is a complex interaction between many different bacteria (a large percentage of which we cannot grow in the lab) and the human host. Yes different genetics seem to be make people more or less resistant to caries and different habits play a key role. Also we know of some bacterial genes that when knocked out result in less or no plaque in the lab, but again, it's only one type of bacterium. In the mouth, if you somehow managed to (legally, ethically, and technically) introduce such mutant bacteria, it is likely that another one will produce the plaque and you're off again. It is just not easy to fix. So trying to spin that this one enzyme from only one type of bacteria found in plaque is responsible for caries and that it is the nail that holds this complex in place is a bit premature and silly.