You might want to check out pythoncard http://pythoncard.sourceforge.net/ http://pythoncard.sourceforge.net/ at least for prototyping. It uses wxPython as the

You might want to check out pythoncard http://pythoncard.sourceforge.net/ http://pythoncard.sourceforge.net/ at least for prototyping. It uses wxPython as the windowing toolkit. It has its own GUI builder built in pythoncard itself. pythoncard is like hypercard but it has all the power of python behind it. I have used it to write little desktop apps and been quite happy with the ease of development (particularly when adding new features after some months) and the performance. I never tried making an exe, but it should be possible.