The AKT1 gene variant, but there's a caveat.[1] genotype T/T: roughly equal risk of psychosis (1.0/1.0/1.0) regardless of marijuana use. genotype C/T: roughly

The AKT1 gene variant, but there's a caveat.[1] genotype T/T: roughly equal risk of psychosis (1.0/1.0/1.0) regardless of marijuana use. genotype C/T: roughly 0.8 risk with no marijuana use, 1.0 risk with occasional use, and 0.9 risk with daily marijuana use genotype C/C: roughly 0.5 risk with no marijuana use, 1.0 risk with occasional use, and 7.0* risk with daily use. It's the daily-use C/C case that is emphasized, but note that it requires frequent use; otherwise, the risk is roughly on par or better than other genotypes. Note: numbers and relative risks may change with better studies. It's unclear if the type/severity of psychosis is statistically the same for different genotypes. So, the conclusion I draw is that only frequent marijuana users should be very concerned. Once a week or less isn't too worrying, but if you absolutely want to take advantage of a half-normal risk of psychosis if you have the C/C variant, consider skipping the marijuana and doing advanced meditation instead? I wonder how difficult it would be (and how much it would cost) to have a portable AKT1 genotype assay available in marijuana dispensaries. That and several other genetic variations, and their implications for marijuana users, are described at http://profofpot.com/genetics-thc-psychosis/ http://profofpot.com/genetics-thc-psychosis/ [1] https://www.drugabuse.gov/publications/research-reports/marijuana/there-link-between-marijuana-use-psychiatric-disorders#akt1 https://www.drugabuse.gov/publications/research-reports/mari...