As some of the other comments have suggested, wxPython is a good choice. It attempts to wrap the native controls where possible, so your app won't look too out

As some of the other comments have suggested, wxPython is a good choice. It attempts to wrap the native controls where possible, so your app won't look too out of place on any one platform. For creating your form layout without code, there is the included XRC editor, which allows you to create dialogs, panels, menus, toolbars, etc. and save those as XML files, which can be loaded and displayed by your application code. http://wiki.wxpython.org/XRCTutorial http://wiki.wxpython.org/XRCTutorial Regardless of how you create you GUI in wxPython, make sure you have a basic understanding of how sizers work to layout your application.