I've found enthought's Traits to be very helpful. It's a MVC framework that can save you from sinking lots of time into writing tedious boilerplate. For anythi

I've found enthought's Traits to be very helpful. It's a MVC framework that can save you from sinking lots of time into writing tedious boilerplate. For anything it doesn't handle automatically, you can write using wxPython. It's a little sparse on the documentation so you'll spend a lot of time looking at the source code to figure our how things work though. They also claim that it's portable but I haven't tried it on anything other than linux.