Does the "huge margins of the healthcare industry" include all the money spent on failed pharma startups? If you spend $1bn on a drug then make $1bn profit but

Does the "huge margins of the healthcare industry" include all the money spent on failed pharma startups? If you spend $1bn on a drug then make $1bn profit but the other 9 drugs failed (after someone having spent $1bn for each) the margin isn't 100%, it's 10%.