Probably not. On the timescales of millions of years, the only thing that really matter is whether it's physically possible, and it looks physically possible to

Probably not. On the timescales of millions of years, the only thing that really matter is whether it's physically possible, and it looks physically possible to colonize other galaxies. http://www.fhi.ox.ac.uk/wp-content/uploads/intergalactic-spreading.pdf http://www.fhi.ox.ac.uk/wp-content/uploads/intergalactic-spr... I'd be pretty surprised if the jump between galactic groups is much worse.